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The integrin LFA-1 (lymphocyte function-associated antigen-1) is a receptor present on lymphocytes that plays, together with its major ligand ICAM-1 (intercellular adhesion molecule 1), an important role in immune cell function. 1,3,4.
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Using intravital confocal microscopy of anesthetized mouse cremaster LFA-1 is expressed on the surface of all leukocytes including lymphocytes monocytes macrophages and granulocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1 (CD54) ICAM-2 (CD102) and ICAM-3 (CD50) and also functions in lymphocyte costimulatory signaling.
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The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ2), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We
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Search results for LFA-1 at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin Guido H. Wabnitz1, Philipp Lohneis1, Henning Kirchgessner1, Beate Jahraus1, Susan Gottwald1,2, Mathias Konstandin3, Martin Klemke1 and Yvonne Samstag1 1 Institute for Immunology, Ruprecht-Karls-University, Heidelberg, Germany 2 National Center for Tumor Diseases and German Repeats‐in‐toxin leukotoxin (LtxA) produced by the oral bacterium Aggregatibacter actinomycetemcomitans kills human leukocytes in a lymphocyte function‐associated antigen 1 (LFA‐1, integrin α L /β 2)‐dependent manner, although the mechanism for this interaction has not been identified.The LtxA internalisation by LFA‐1‐expressing cells was explored with florescence resonance FOR SALE; LEXUS LFA // 1 OF 500 // SWISS LHD // 4K MILES // FULL LEXUS HISTORY EQUIPMENT 6-Speed Semi-Automatic, CFRP Chassis + Body Construction, Titanium Rear Silencer, Titanium Valves, Forged Pistons, (212) Black, Forged 20″ Dark Premium Metallic Wheels, Ceramic Composite Brakes, Red Callipers, Black Leather Heated 8-Way Adjustable Seats, Black Leather Dashboard + 2017-12-12 Plasmid Human LFA-1 alpha from Dr. Timothy Springer's lab contains the insert LFA1 alpha and is published in J Cell Biol 1989 Feb;108(2):703-12.
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7 Views. •. Differential regulation of LFA-1 and ICAM-1 on human primary B-lymphocytesmore. Men man vet också att receptorn LFA-1, som sitter på T-cellerna, kan starta en process där T-cellerna aktiveras och attackerar transplanterade Page 1. TUV - projektets resultat / LFA matris.
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